The aim of our research is to gain a stronger understanding of how the cytoskeleton is regulated during events such as cytokinesis (cell division) and epidermal morphogenesis. This includes an in-depth molecular analysis of anillin, a conserved actin and myosin binding protein that is a key component of the contractile ring required for cytokinesis. This work is being done in mammalian cells and the nematode Caenorhabditis elegans.
To get a better idea of the research that we are pursuing in the lab, please visit the areas of research indicated below or the project descriptions of our current lab members.
Z-projections of fixed HeLa cells co-stained for tubuin (red), anillin (green) and DNA (DAPI, blue). Inverted tubulin images are shown underneath. Anillin is initially cytosolic, then accumulates at the cortex as cells exit mitosis.
Time-lapse images of an adherens junction marker, AJM-1, tagged with GFP in a developing C. elegans embryo. These images show ventral enclosure, a key step in epidermal morphogenesis when the ventral epidermal cells migrate to cover the belly of the embryo in a sheet of epidermis.